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Although a plethora of tumor cell mechanosensors have been identified, including focal adhesions, ion channels, actin cytoskeleton, nuclear proteins, and transcription factors, more research is needed to uncover how breast cancer cells convert biophysical signals into biochemical cues to mediate short- and long-term mechanoresponses ( Table 5 )

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In addition, people are exposed to increased oxidative stress due to environmental factors such as UV, ozone or pollution, but smokers and people with chronic use of medications such as paracetamol or cytostatic drugs also have a higher need for antioxidants