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[1] Niacinamide in high doses can sometimes cause nausea, heartburn, or a sensation of warmth

For example: A 50-year-old, male patient undergoes an open cholecystectomy under general anesthesia

Some symptoms, from more minor to severe, impaired judgment and coordination walking difficulty slurred speech mood change behavior change nausea vomiting low body temperature memory loss double vision involuntary eye movement trouble breathing coma respiratory failure heart rhythm changes liver failure Chronic alcohol poisoning leads to alcohol-related liver disease

Connective tissue massage, manual lymphatic drainage, and Shiatsu have also shown promising effects in clinical trials

Nishida et al