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However, since blunted IGF-IR activity in the PeF area induces changes in the ECG, as seen in the Firoc mouse, and until now only orexin neurons are known to produce these changes 38 , we may conclude that most of our results may be explained by a direct activation of orexinergic neurons by IGF-I, facilitating in this way wakefulness

normalized AGC target: 300%) and 40 periodical MS/MS segments applying isolation windows based on peptide prediction in MaxQuant.live (resolution: 30,000

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Loss of Fsp1 aggravated renal dysfunction and amplified oxidative stress in oxalate-induced AKI mice In addition, we developed a renal tubule-specific Fsp1 knockout mouse model Fsp1 fl/fl Ksp Cre-ERT2 (Fig