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People with Leber hereditary optic neuropathy should not receive cyanocobalamin

Scientists found that in obese mice, MOTS-c treatment reversed diet-induced obesity and insulin resistance the mice shed weight and their blood sugar control improved

4 Donaldson MS

Semaglutide does not directly affect intrinsic factor production, but the reduced stomach acid environment can compromise the initial separation step that makes b12 available for intrinsic factor binding

Vitamin B12 monitoring is not routinely indicated for patients on GLP-1/GIP therapy alone but may be considered for those also taking metformin or with risk factors for deficiency