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The hyporesponsiveness of neutrophils, combined with this dysbiosis could be involved in disease progression, but usually tissue neutrophils are often poorly analyzed, and more studies are necessary to fully understand the role of neutrophils at mucosal surfaces and their association with STI risk disease progression (117)

The slides were then stored in a humidified container and analyzed within 24 h

The American Academy of Family Physicians and NIH identify the following clinical manifestations: Fatigue and generalized weakness Megaloblastic anemia (abnormally large, immature red blood cells) Tingling or numbness in the hands and feet (peripheral neuropathy) Difficulty walking and balance problems Cognitive disturbances including memory difficulty and confusion Mood changes, including depression and irritability Glossitis (swollen, inflamed tongue) Early symptoms such as fatigue and mild tingling are often attributed to stress, aging, or other conditions

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Conflict of interest Author YC was employed by Power China Chengdu Engineering Corporation Limited