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This research was supported by the National Key Research and Development Program of China (2017YFC0906900, 2017YFA050400, 2016YFA0100602, and 2017YFA0103302), the NSFC (31722033, 91649123, 31671484, 31225008, 31470833, 91749203, 81525010, and 81420108017), the Shanghai Science and Technology Commission (14XD1401400, 16430723100, and 15YF1402600), the Young Elite Scientists Sponsorship Program by Cast, Shanghai Young Top-notch Talent, the State Key Laboratory of Bioreactor Engineering, the Fundamental Research Funds for the Central Universities, the US National Institutes of Health (HL061795, HG007690, and GM107618 to J.L.), and the American Heart Association (D700382 to J.L.)

Elevated cortisol levels from stress can lead to skin sensitivity, breakouts, and inflammation, which often result in post-inflammatory hyperpigmentation (PIH)

Mitochondrial dysfunction as a trigger of programmed axon death

Dubler RE, Anderson BM: Simultaneous inactivation of the catalytic activities of yeast glutathione reductase by N-alkylmaleimides

The comorbid mechanisms are complex, posing challenges for clinical treatment