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Ascorbic acid plays a role as a redox cofactor and catalyst in a biological system such as in the conversion of the neurotransmitter dopamine to norepinephrine, in peptide amidation, and in tyrosine metabolism

L.AskariB.KramerF.BarnhartS.Vivekanandan-GiriA.PennathurS.et al (2011)

In culture, somatic cells have limited replication potential reaching a time point at which cell division ceases

Sorafenib causes the production of P62, which inhibits NRF2 degradation and promotes the inactivation of KEAP1, followed by the activation of heme oxygenase-1 (HO-1), quinone oxidoreductase-1, and ferritin heavy chain-1, which enhances NRF2 nuclear localization