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Endometrial cancers associated with Lynch syndrome (LS) are characterized by high microsatellite instability (MSI-H), which influences treatment decisions and makes these tumors particularly responsive to immunotherapy (47)

J Biol Chem (1992) 267:135937

The form, dose, and timing are worth recording, and further workup becomes necessary if the elevation persists once those sources are accounted for, or if symptoms, examination findings, or other labs raise concern