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However, knockout mice were not protected from hepatic steatosis induced by a high fat diet, potentially due to decreased fatty acid oxidation caused by a compensatory increase of ACC2, which in turn inhibited mitochondrial -oxidation [58]

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Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers

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For high-fat diet experiments, mice were fed a 60 kcal% fat high-fat diet (Research Diets, D12451i) following either tamoxifen or AAV-TBG-Cre injection for 2-3 weeks