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233 While all methods that have moved away from individual protein purification sacrifice some control over PUREs composition, they circumvent the high cost and laborious nature of producing PURE, which are two of the main barriers to its use

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doi: 10.1186/s12888-025-06734-2 63 VermaMKaurAUpnejaADhoatPAnejaJKakkarR

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Figure 3 In addition to leveraging the EPR effect of nanoparticles, targeting ligands can be anchored on the nanoparticle surface to actively direct cytokines to specific cells or tissues