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While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition

Daily use is generally safe for most people, but start gradually to allow your skin to adjust

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Youve got a couple of main routes, and each comes with its own set of pros and cons