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89 In addition to ONOO -mediated oxidation of BH 4 , there may be also an intracellular decrease because of decreased synthesis by inhibition of the GTP cyclohydrolase I ( de novo synthetic pathway) or by inhibition of the so-called salvage pathway involving enzymes such as the sepiapterin synthase, the sepiapterin reductase or the dihydrofolate reductase

[DOI] [PubMed] [Google Scholar] 349.Wu H

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Initially, 75% A and 25% B were used to elute for 5 min, followed by 25% A for 8 min, 10% A for 10 min, 100% B for 5 min, and, finally, 75% A and 25% B for 7 min