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Samples with different expression pattern are highlighted (yellow)

Conversely, cuproptosis, a copper-induced cell death triggered by the accumulation of Cu in mitochondria, leads to the aggregation of lipoylated dihydrolipoamide S-acetyltransferase (DLAT) and a loss of Fe-S protein, which are associated with energy formation in the tricarboxylic acid cycle (TCA), leading to proteotoxic cellular stress, eventually leading to cell death [7]

There were four blocks with 40 trials

However, the connection between iron metabolism and T2D, along with its consequences, remained ambiguous until the identification of ferroptosis

She served as vice chair of the Central Pacific regional board of the Anti-Defamation League and had been nominated to the national board prior to her illness