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Nonetheless, the in vitro and in vivo lessons together have taught us that an appropriate, dynamic, and physiological regulation of both mTORC1 activity and autophagy is necessary for adipogenesis and for maintaining the correct accumulation and mobilization of lipids and the physiological functioning of WAT (Table 1)

Gene set enrichment analysis (GSEA) was performed with GSEA v4.1.0 software ( GSEA identifies functional enrichment by comparing genes with predefined gene sets