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This observation contrasts with other normal and malignant proliferative cells such as intestinal and cancer cells that display reduced proliferation upon G6PDH inactivation 26

As with lipedema, obesity is also a strong exacerbator of lymphedema (lymph fluid accumulation/swelling), can induce the onset of lymphedema in patients predisposed to it, and at high enough levels of obesity, can even induce lymphedema in patients who have no known predisposing risk factors

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doi: 10.1080/09603123.2022.2093841