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this alteration represents a newly discovered mechanism by which the antidepressant drug exerts its effect

TAMs adjust their activation state, synthesis of inflammatory cytokines, and proliferation of peroxisomes by modulating glutamine metabolism [123]

Results from this study showed no significant effect of low-dose amitriptyline on neuropathic symptoms (mean global improvement of 3.4 3.6 in the amitriptyline group and 1.9 3.1 in the placebo group)

Antioxid Redox Signal 38:599618 Che X, Brydges CR, Yu Y, Price A, Joshi S, Roy A, Lee B, Barupal DK, Cheng A, Palmer DM, Levine S, Peterson DL, Vernon SD, Bateman L, Hornig M, Montoya JG, Komaroff AL, Fiehn O, Lipkin WI (2022) Evidence for peroxisomal dysfunction and dysregulation of the CDP-choline pathway in myalgic encephalomyelitis/chronic fatigue syndrome

Cozma, P., Roca, M., Minu, M., & Gavrilescu, M