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For the comet assay experiments, cells were seeded at a density of 2 10 5 cells/ml per well in 24-well plates and cultured for 24 h prior to treatment

Mechanistically, the activation of the MAPK/ERK pathway plays a major role in promoting competition between tumor cells and T cells for glutamine uptake

Yin C, Li Z, Xiang Y, et al

Off-target resistance The susceptibility of cancer cells to CDDP can also be limited by off-target mechanisms, that is, molecular circuitries that deliver compensatory survival signals even though they are not directly activated by CDDP