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Diabetic wounds represent particularly challenging healing scenarios, making these results especially significant

Freeze/thaw cycles can degrade peptide structure and should generally be avoided

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71,72 To account for differences between drugs, such as the 1 AR antagonist activity of carvedilol, we ran sensitivity analyses with each drug removed and found similar risks (data not shown), suggesting that our results cannot be attributed to any single compound

Insulin sensitivity increased substantially across all dose groups