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And the benefits might be partly result from decrease in lectin-like oxidized receptor1 (LOX-1) followed by significant declines in cellular ROS and NF-B signaling pathways

Once the microglia engulf the senescent neurons, they become senescent, dysfunctional and amplify pathogenesis through inflammation, releasing toxic tau and failure to survey the brain microenvironment

BMC Gastroenterol 25 , 68 (2025)

Grimm, D

More importantly, EBV-encoded miRNAs compromise the attraction of CD8 + T cytotoxic lymphocytes into the tumor microenvironment by down-regulating CXCL11 expression and also inhibit antigen presentation on MHC class I molecules to these CD8 + T cells, rendering the microenvironment of EBV-associated malignancies immune-suppressive