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doi: 10.1212/WNL.38.8.1285 22 McGeerPLMcGeerEG

This pathway is centred on the enzyme ADH5 and it is downstream of the de novo GSH synthesis pathway (Fig

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The process can be initiated by elevated glucose or insulin, and liver X receptor A, thereby promoting hepatic lipid accumulation and regulating to lipid-producing genes such as Acetyl-CoA Carboxylase (ACC), Stearoyl-CoA Desaturase-1, and Fatty Acid Synthase (FASN) (Geidl-Flueck and Gerber 2023

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