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Several neurological manifestations including cognitive dysfunction are often described in such patients

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Ang I is formed from angiotensinogen by renin, and converted into Ang II by angiotensin-converting enzyme (ACE), which activates AT 1 and AT 2 receptors

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A few of the more common birth defects this drug can cause are hearing and visual impairment, missing or malformed earlobes, facial dysmorphism, and abnormalities in brain function