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The IL-1, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19

Activation of this pathway enhances antioxidant gene expression, offering neuroprotection

Likewise, the roles of neuro-inflammation and oxidative stress have often been indicated in in vitro and in vivo experiments, justifying a therapeutic approach also focused on these mechanisms (Liu and Wang, 2017

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In a study of healthy trained men supplementing with 2.4 g of Cit per day for eight days, cycle ergometer trial completion times were reduced, average power output was increased, and subjective concentration and fatigue were also improved [126]