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Lenvatinib inhibited cell growth in a concentration-dependent manner, and this effect was reduced under hypoxia with an IC 50 (normoxia/hypoxia, M) of 13.1/21.6 in PLC/PRF/5 and 22.7/25.0 in HepG2

Precisely, superoxide anion and hydrogen peroxide have been reported to act as mitogens, thereby promoting the rate of DNA replication and cell proliferation in a variety of cultured cells.9, 10 Nonetheless, in excess amounts, oxygen-derived radicals are very harmful to living organisms

Heterogeneous multimeric structure of isocitrate lyase in complex with succinate and itaconate provides novel insights into its inhibitory mechanism

Both changed measured wrinkles and pigmentation, while the retinol group reported more scaling and stinging