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It should be noted that upon transduction of the cells with the variant library, there was a ~50% loss in total variant representation (Fig

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This is further supported by Zhang et al., who demonstrated that impairing the GLO pathway specifically disrupts the production of Kce and Kd-la, while the generation of lactyl-CoA appears to be positively correlated with Kl-la [18] (Fig

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doi:10.1186/gm368