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Common Side Effects 1

By contrast, USP30, a deubiquitinase (DUB) that localizes on the OMM, antagonizes Parkin-mediated mitophagy by removing ubiquitin from mitochondrial proteins

Key considerations when switching: Allow a washout period based on tirzepatide half-life Start retatrutide at the standard 1mg initiation dose regardless of previous tirzepatide dose Expect renewed GI side effects as the glucagon receptor is a new stimulus Monitor heart rate more carefully during the initial escalation period When tirzepatide is the better choice Tirzepatide remains the superior option in several specific situations

Weickert 2018)

Ce dernier transporte les lipides du foie vers les tissus priphriques et notamment vers le tissu adipeux