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The hypoxic environment can induce glucose metabolism through HIF, which can lead to drug resistance in tumor cells (Sun et al., 2021)

PDK1-deficient erythrocytes exhibit a reduced cytosolic Ca 2+ concentration and eryptosis upon exposure to cellular stressors [153]

Here, our study elucidated the pivotal role of GGCT in driving hepatocellular cancer (HCC) and prostate cancer (PCa) progression by orchestrating Gln partitioning between redox homeostasis and the TCA cycle