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However, there is some evidence that it might benefit people exposed to brief periods of severe physical exercise (marathon runners) or cold environments (skiers and soldiers in subarctic conditions)

However, endemic populations exhibit a multiplicity of distinctive disease transmission, exposure, pathogenesis, genetic and environmental factors that result in immunological challenges as summarized in Table 1

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For people on vegetarian or vegan diets, up to 90% have a vitamin B12 deficiency: even those who take extra vitamins

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