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Also, BDNF secreted by glial cells would activate TrkB signaling in neurons, through the MAPK/ERK and PLC/IP3 pathways that upregulate CREB, leading to increased neurogenesis and enhanced long-term potentiation (LTP), which were reduced by chronic alcohol consumption (Figure 1)

Allergy to vitamin (any kind

Both Fan et al

J Nutr (2017) 147:14938

The intrinsic pathway is triggered by diverse intracellular stresses, such as DNA damage, metabolic perturbations, or endoplasmic reticulum stress, leading to mitochondrial outer membrane permeabilization (MOMP)