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Acta Trop 232:106537

Systemic chemotherapeutic agents, particularly cyclophosphamide (CPX) and other nitrogen mustard alkylating agents, cause severe clinical manifestations such as cystitis (102)

K., Bonfils, C., & National Cancer Institute of Canada Clinical Trials Group

Using a Cre-inducible viral vector system to overexpress SIRT1 selectively in dopamine D1 or D2 subpopulations of medium spiny neurons (MSNs) in the NAc indicated that SIRT1 promotes depressive-like behaviors only when overexpressed in D1 MSNs, with no effect seen in D2 MSNs

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