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ROS also stabilizes MAPK activation indirectly by inactivating MAPK phosphatases (MKPs): Oxidation of catalytic cysteines prevents their dephosphorylation activity [71], and oxidative stress can induce MKP degradation [72]

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10.1016/j.jgr.2021.10.002 78 PaulS.GangwarA.BhargavaK.AhmadY

R.JacobA.YangW

Complex I can cycle between A and D-forms which is dependent on NADH and ubiquinone (Grivennikova et al., 39 on Complex I subunit ND3, which forms part of the P-module, becomes exposed upon A to D transition and can then be modified by alkylating agents