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Myeloid-derived suppressor cells (MDSCs) and activated tumor-associated macrophages express ARG1, which consumes arginine to form a microenvironment that is not conducive to T cells, resulting in tumor immunosuppression (Rodriguez et al., 2017

Blocking this axis may restore immunosurveillance, thereby halting pathological signal propagation (Steelman and Li, 2014

Castro GA, Carvalho JE, Tinti SV, Possenti A, Sgarbieri VC

R.LeeJ.LeeD.NhoB.KimS

My interest in ME/CFS research first emerged out of nowhere in 2002 after I had the opportunity to conduct diagnostic (as opposed to research) brain MRI/MRS evaluations and metabolic workup in patients with ME/CFS, who turned out to be patients of Dr