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Another study reported that a humanmouse monoclonal antibody binding to methylphenidate, named anti-METH antibody (mAB7F9), elicited a significant reduction in the METH concentration ( Drugs for Chronic Damage Long-term exposure to METH leads to DA depletion, impairment of dopaminergic markers, and neuronal degeneration ( cis -retinoic acid (9cRA), a biologically active derivative of Vit.A, reversed the METH-induced decrease in immunoreactivity and apoptosis of T-helper cells via inhibition of the export of nuclear receptor 77 from the nucleus to the cytosol in primary cultured dopaminergic neurons