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[1] [4] When B12 is deficient, myelin production is impaired, leading to demyelinationthe breakdown of this protective sheathwhich results in abnormal nerve signalling perceived as pain, tingling, or numbness

10.1038/s41586-020-2223-y Nature 28 KochH

The study of nuclear compartmentalization of GSH poses a significant methodological challenge and the findings were controversial over the last decade

Recent evidence highlights that sodium-glucose cotransporter 2 (SGLT2) inhibitors, such as canagliflozin, attenuates VC in CKD rats by suppressing NLRP3-mediated cytokine release, suggesting a therapeutic avenue (59)