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However, the development of ex vivo slice culture models has provided an alternative model that bridges the gap between in vitro and in vivo models, enabling the investigation of demyelination and remyelination under controlled conditions, with the added advantage of reduced cost and ethical considerations (Humpel, 2015)

During the subacute phase of the pathology, lactate can be utilized as an alternative energy source by some surviving neurons and astrocytes, while concurrently promoting angiogenesis and tissue repair through receptor-mediated signaling (129)

The lungs are directly exposed to tobacco smoke and air pollutants that are main sources of ROS

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