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Long-term use is not only safe but generally recommended to maintain the youthful, wrinkle-softening benefits

Dose and route heterogeneity: animal studies use very variable doses (from 10 nanograms to 10 micrograms per kg) and different routes (intraperitoneal, subcutaneous, intravenous, oral), which complicates comparisons between protocols and establishing a clear dose-response relationship

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Similar results have also been shown in rat models investigating the healing of the medial collateral ligament (MCL) following surgical transection (Cerovecki et al