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Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain

Chang, S., Hsu, S., Tien, K., Hsiao, J., Lin, S., Chen, H., & Hsieh, M

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9 Increased G3PS activity may promote longevity by increasing the cytoplasmic [NAD + ]/[NADH] The G3PS enzyme GPD1 localizes to the cytoplasm, while the other G3PS enzyme GPD2 is attached to the intermembrane space side of the IMM (Figure 2A)