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Description

In addition, ROS contribute to the maintenance of a proinflammatory state, secondary to secretion of cytokines and chemokines (Hsieh and Yang, 2013

Zhang and Wei, 2020)

, Greig N

Acta 84 , 11971206 (2001)

Under proinflammatory stimulus, the IKK complex can be activated by ROS produced by the GTP-binding protein Rac1 (116), leading to signal transduction pathways that contribute to TNF- secretion