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Alternative activation of macrophages is induced by IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergic, cellular and humoral responses to parasitic and selected pathogen infections

Smolarek TA, Higgins CV, Amacher DE: Metabolism and cytotoxicity of acetaminophen in hepatocyte cultures from rat, rabbit, dog, and monkey

10.1007/s43032-021-00699-9 62 KalafatE.SukurY

These kinases phosphorylate the membrane transporters (DAT, NET, SERT), leading to two outcomes: the transporters are either internalized into the cell (ceasing all reuptake function) or they undergo a conformational shift that causes them to operate in reverse

The single layer of intestinal epithelial cells (IECs), which renews every 35 days, includes intestinal stem cell (ISCs) located at the bottom of each intestinal crypt as well as progenitors which undergo cell proliferation in the transit amplifying zone following Wnt signaling activation (Beumer and Clevers, 2021)