The research was supported in part by the National Institute of Dental and Craniofacial Research (R01DE025037 and R01DE027374).
The ranges you will see in this guide come from two sources: preclinical research, which is mostly rodent and cell-culture work, and clinical-practice observation, meaning what providers and patients consistently report

sudden cardiac death due to arrhythmias Treatment: Management for HC ingestion is supportive (no specific antidotes are available) Observe patients in a monitored setting for signs of respiratory distress Cardiac monitor and pulse oximetry are recommended Patients who show signs of impending respiratory failure, despite supplemental oxygen, may require rapid intubation & ventilation Decontamination of the GI tract generally is not recommended because of the risk of aspiration and the low GI toxicity of most HCs Indicated medications include dextrose, thiamine, and naloxone for altered mental status and albuterol for bronchospasm Notes: The American Association of Poison Control Centers lists HCs as the 12th most common poison exposure In 1997, 3% of cases reported to US poison control centers involved HC exposure

The Rag complex is in turn tethered to the lysosomal membrane via another multi-subunit complex called Ragulator that interacts with the lysosomal V-ATPase and the amino acid transporter SLC38A9 71,72
Higher absorption, faster results, and bypassing digestive limitations