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The remaining four SOCs met only the ROR algorithm criteria, as shown in bold in Table 2

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Abbreviations AD Alzheimer's disease Akt protein kinase B ALS amyotrophic Lateral Sclerosis AMPK AMP-activated protein kinase APP amyloid precursor protein A amyloid beta BBB Blood-brain barrier BDNF brain-derived neurotrophic factor c-AMP c-adenosine monophosphate CA cornu ammonis CAT Catalase CGA chlorogenic acid CREB cAMP response element-binding protein CRP c-reactive protein EC Epicatechin ECG epicatechin gallate EGC Epigallocatechin EGCG Epigallocatechin-3-gallate ERK extracellular signal-regulated kinase FABP fatty acid-binding protein GA glutamic acid GLUT glucose transporter GPR G-protein coupled receptor GPx glutathione peroxidase GSH Glutathione GSK3B glycogen synthase kinase 3 HD huntington's Disease Keap1 kelch-like ECH-associated protein 1 MPTP 1-methyl-4-phenyl-1,2,3,6-tetrahydopyridine MS Multiple Sclerosis NA pyridine-3-carboxylic acid NAD Nicotinamide NADP nicotinamide adenine dinucleotide phosphate NADPH oxidase nicotinamide adenine dinucleotide phosphate hydrogen oxidase NF-B nuclear factor kappa B NO nitric oxide NPE neuroprotective effects NRF2 nuclear factor erythroid 2-related factor OS oxidative stress PC12 pheochromocytoma-12 PD Parkinson's disease PKC protein kinase C PLP pyridoxal-5-phospate PPAR peroxisome proliferator-activated receptor- Prxs Peroxiredoxins RAR retinoic acid receptor RNS reactive nitrogen species ROS Reactive oxygen species SGLT sodium-glucose cotransporter SOD superoxide dismutase STZ Streptozotocin T2D Type 2 diabetes TGF-1 Transforming growth factor (TGF)-1 Trx Thioredoxin Appendix A

By integrating preclinical findings with emerging therapeutic strategies, we aim to provide a forward-looking perspective on ASTs role in neurodegeneration