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Zinc modulates the expression of glutamate cysteine ligase, referred to as -glutamylcysteine synthetase (-GCS), which is the enzyme that catalyzes the initial and rate-limiting step in the biosynthesis of the tripeptide glutathione (GSH), one of the most efficient intracellular antioxidants

& Jang, K

DL, Drug-likeness

[DOI] [PubMed] [Google Scholar] 106.Tomita M, Kawakami H, Uchihara J, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y, and Mori N

To mimic ischaemia, some hearts were removed and then incubated ex vivo at 37 C for 30 min under ischaemic conditions, which are known to replicate the metabolic changes that occur during ischaemia in vivo 53