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Primary carnitine deficiency, secondary carnitine deficiency (fatty acid oxidation disorders, organic aciduria, mitochondrial disorders), part of a ketogenic diet, treatment of epilepsy with valproate in monotherapy or in combination

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NAC improves hepatic glutathione levels, reduces oxidative stress, improves insulin sensitivity, and supports detoxificationmaking it highly relevant in NAFLD/NASH management

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Many proteins which underwent dysregulated abundance under both basal and ROS conditions were reductases, oxidases, stress response proteins and enzymes with oxidising products (Supplementary Tables S3 and S4)