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Additionally, TRPM7 contributes to the accumulation of Zn 2+ in mouse cortical neurons, and inhibiting TRPM7 with 2-APB or sh-RNA reduced Zn 2+ -induced neuronal damage [59]

J Nutr Biochem 2013;24:894902

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Patients who do not respond adequately to UDCA may be considered for second-line therapies, typically after 1 year, potentially delaying effective treatment for high-risk patients