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The carrageenan-induced increase in the levels of the cytokine-inducible nitric oxide synthase, IL-1, and IL-6 was abrogated following treatment with CBC

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and iii) increased oxidative stress, due to the putative role of thiamine in prostaglandin expression, decreased lipid peroxidation as well as expression of nitric oxide synthase (143, 144), and its involvement as a cofactor for TKT in the PPP, master regulator of NADPH homeostasis