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Furthermore, in parkinsonian model, the stereotaxic injection of human NSCs into the substantia nigra resulted in improvements in behavior and movement, which was linked to the capacity of the transplanted NSCs to differentiate into tyrosine hydroxylase- and dopamine transporter-positive cells in the substantia nigra [208]

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The mitochondria rapidly depolarized in a dose-dependent manner, suggesting that colistin directly targets the mitochondria (unpublished data) (Figure 5)