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In general, the shorter the half-life, the more sensitive the dose is to absolute changes in half-life

It should be noted that alanine mutated Y313 7.43 reduced the surface expression of the receptor

P., Huang, Z

10.1016/j.ijpharm.2024.124799 76 ParseghianC

If the liver were primarily taking D-lactate up from plasma, it would be completely impossible for it to generate a 28,571-fold differential favoring the L form in blood when it removes the L form faster than the D form