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Furthermore, loss of amylo-1,6-glucosidase (AGL), a glycogen debranching enzyme, leads to elevated SHMT2 levels, which in turn increases glycine and purine nucleotide synthesis and further supports tumor cell proliferation (78)

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Glutathione supplements have been shown to aid the liver in eliminating toxins and heavy metals that can cause serious illnesses

the GSTM1-null genotype does not lead to an enzyme production, subsequently the binding of reactive platinum compounds to glutathione is not catalysed and the excessive damage to the SECs manifests itself in SOS