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MTAP deficiency creates an exploitable target for antifolate therapy in 9p21-loss cancers

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that oxidation of Cys residues in STAT3 into disulfide(s) would block its activation, but our findings clearly suggested that STAT3 function is fully TrxR1-dependent

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Cycling recommendations are less established due to the early stage of human research, but the general principle of periodic breaks applies

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Curr Treat Options Oncol 19(5):25, 2018

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