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The age-related decline is real but we dont know if topping it up helps

Directly supplementing with oral reduced glutathione (L-GSH), however, presents a fundamental pharmacokinetic challenge: GSH has a plasma half-life of approximately 1.6 minutes, undergoes rapid hydrolysis in the gut by intestinal -glutamyl transpeptidase (-GT), and cannot cross cell membranes intact requiring full breakdown into constituent amino acids and intracellular resynthesis

Todorova V, Vanderpool D, Blossom S, Nwokedi E, Hennings L, Mrak R, et al

These conditions affect how long b12 stays in the body, as individuals may not absorb enough of the vitamin from food or supplements

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