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Given that low lactate dehydrogenase levels represent a high mitochondrial metabolic state, this finding is consistent with the observation that cells with high levels of lipoylated TCA enzymes and a hyperactive mitochondrial respiratory rate are more sensitive to elesclomol

Further, the decrease in GCase activity is also associated with ER stress triggered by the unfolding of mutant GCase and impaired mitophagy [13]

Liu H-J, Tang Z-X, Han X-M, Yang Z-L, Zhang F-M, Yang H-L, Liu Y-J, Zeng Q-Y

Chollet A, Mourey L, Lherbet C, Delbot A, Julien S, Baltas M, et al

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